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Close-up of the Ultimate Tender Brisket Sandwich, showcasing its juicy, smoky brisket, creamy special sauce, vibrant pickled onions, and crisp lettuce in a toasted artisan roll on a rustic cutting board.

Perfect Brisket Sandwich


  • Author: Stephanie
  • Total Time: 10-12 hours
  • Yield: 4-6 sandwiches

Description

This mouthwatering brisket sandwich features perfectly seasoned, fall-apart tender beef topped with a creamy special sauce on toasted artisan rolls. Whether smoked, slow-cooked, or oven-roasted, this foolproof recipe delivers restaurant-quality results with a smoky exterior and juicy interior that will impress family and friends. The ultimate way to enjoy brisket between bread!


Ingredients

For the Brisket:

  • Beef Brisket – 4-5 pounds
  • Kosher Salt – 2 tablespoons
  • Freshly Ground Black Pepper – 2 tablespoons
  • Garlic Powder – 1 tablespoon
  • Onion Powder – 1 tablespoon
  • Smoked Paprika – 1 tablespoon
  • Brown Sugar – 1 tablespoon
  • Beef Broth – 1 cup

For the Special Sauce:

  • Mayonnaise – 1/2 cup
  • Dijon Mustard – 2 tablespoons
  • Honey – 1 tablespoon
  • Apple Cider Vinegar – 1 tablespoon
  • Prepared Horseradish – 1 teaspoon
  • Fresh Black Pepper – 1/2 teaspoon

For Assembly:

  • Artisan Sandwich Rolls – 4-6
  • Pickled Red Onions – 1/2 cup
  • Crisp Lettuce – 4-6 leaves
  • Sliced Tomatoes – 1 medium
  • Sliced Cheese (optional) – 4-6 slices

Instructions

Prepare the Brisket:

  1. Trim the brisket, leaving about 1/4 inch of the fat cap intact.

  2. Combine kosher salt, black pepper, garlic powder, onion powder, smoked paprika, and brown sugar in a small bowl to create your dry rub.
  3. Apply the rub generously to all sides of the brisket, pressing firmly into the meat. Wrap in plastic and refrigerate overnight for best results (or at room temperature for 1 hour if short on time).

Cook the Brisket:

  1. Preheat smoker to 225°F with your preferred wood chunks.
  2. Place brisket fat side up on smoker grates and insert a probe thermometer.
  3. Maintain temperature between 225-250°F throughout cooking.
  4. Spritz with apple cider vinegar/water mixture hourly after the first 3 hours.
  5. Cook until internal temperature reaches 165°F (typically 6-8 hours).
  6. Wrap tightly in butcher paper or foil with 1/4 cup beef broth added.
  7. Continue cooking until internal temperature reaches 203°F and probe slides in easily (2-4 more hours).

Rest & Prepare:

  1. Rest the cooked brisket for at least 1 hour (preferably 2) while wrapped.
  2. Make the sauce by combining all sauce ingredients in a small bowl. Refrigerate for 30 minutes.
  3. Slice brisket against the grain into thin 1/8-inch slices.
  4. Toast sandwich rolls until just golden at the edges.

Assemble:

  1. Spread special sauce generously on both top and bottom halves of each roll.
  2. Layer 4-6 ounces of sliced brisket on bottom half.
  3. Top with pickled red onions, lettuce, tomato, and cheese if using.
  4. Close the sandwich and press gently before cutting in half to serve.

Notes

  • Choose the right cut: The point end (fattier) works best for sandwiches rather than the leaner flat end.
  • Temperature trumps time: Cook to temperature (203°F), not time, for perfect tenderness.
  • For juicier meat: Refrigerate the whole brisket overnight after initial rest, then slice and gently reheat in its juices the next day.
  • Prevent dry brisket: If your brisket seems dry, slice it thinner and dip slices in accumulated cooking juices.
  • Spicier variation: Add 1/2 teaspoon cayenne to the rub and 1 teaspoon hot sauce to the special sauce.
  • Storage: Refrigerate sliced brisket in its juices for up to 4 days or freeze for up to 3 months.
  • Prep Time: 30 minutes
  • Rest Time: 1-2 hours
  • Cook Time: 8-10 hours
  • Category: Lunch
  • Method: Smoking
  • Cuisine: American

Nutrition

  • Serving Size: 1 sandwich
  • Calories: 640 kcal
  • Sugar: 8g
  • Sodium: 980mg
  • Fat: 32g
  • Saturated Fat: 12g
  • Unsaturated Fat: 18g
  • Carbohydrates: 38g
  • Fiber: 2g
  • Protein: 48g
  • Cholesterol: 125mg